CROSSLINKING BRANCHED MOLECULE THROUGH THIOL-DISULFIDE EXCHANGE TO FORM HYDROGEL,申请号US200913509978-传众专利搜索

CROSSLINKING BRANCHED MOLECULE THROUGH THIOL-DISULFIDE EXCHANGE TO FORM HYDROGEL

申请公布号：US2012232027(A1)

申请号：US200913509978

申请日期：2009.11.24

申请公布日期：2012.09.13

申请人：

WU DECHENG;LIU YE;LAY CHEE LENG;AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH

发明人：WU DECHENG;LIU YE;LAY CHEE LENG

分类号：A61K31/704;A61K31/337

主分类号：A61K31/704

摘要：In a process for forming a hydrogel, a precursor crosslinkable through disulfide bonds for forming the hydrogel is provided in a solution. The precursor comprises a branched molecular structure, which comprises a plurality of branches. At least three of the branches each comprises a disulfide bond. The pH in the solution is adjusted to initiate thiol-disulfide exchange in the precursor, thus crosslinking the precursor through disulfide bonds formed by thiol-disulfide exchange. After the precursor is sufficiently crosslinked to form a hydrogel, the pH in the solution is adjusted to inhibit further thiol-disulfide exchange in the hydrogel. Further, a hydrogel matrix may comprise a polymer substantially crosslinked through disulfide bonds. The polymer may comprise a hydrophobic poly(amido amine) core and an amino-functionalized hydrophilic shell.