PROCESS FOR PREPARING EFAVIRENZ POLYMORPH,申请号US20080863808-传众专利搜索

PROCESS FOR PREPARING EFAVIRENZ POLYMORPH

申请公布号：US2012232069(A1)

申请号：US20080863808

申请日期：2008.12.22

申请公布日期：2012.09.13

申请人：

PARTHASARADHI REDDY BANDI;RATHNAKAR REDDY KURA;RAJI REDDY RAPOLU;MURALIDHARA REDDY DASARI;SUBASH CHANDER REDDY KESIREDDY;HETERO RESEARCH FOUNDATION

发明人：PARTHASARADHI REDDY BANDI;RATHNAKAR REDDY KURA;RAJI REDDY RAPOLU;MURALIDHARA REDDY DASARI;SUBASH CHANDER REDDY KESIREDDY

分类号：C07D265/12;A61K31/536;A61P31/18

主分类号：C07D265/12

摘要：The present invention relates to a process for the preparation of crystalline non-hygroscopic form H1 of efavirenz, and pharmaceutical compositions containing it. In accordance with the present invention efavirenz was dissolved in acetone at 25° C.-30° C., the solution was slowly added to water at 0° C.-5° C., the separated solid was filtered, washed with mixture of acetone and water and dried at 25° C.-35° C. under below 65% relative humidity for 18 hours to give crystalline non-hygroscopic efavirenz form H1.