Dendritic cell-associated lectin-like molecules, compositions and methods of use,申请号US20070620582-传众专利搜索

Dendritic cell-associated lectin-like molecules, compositions and methods of use

申请公布号：US8246959(B1)

申请号：US20070620582

申请日期：2007.01.05

申请公布日期：2012.08.21

申请人：

CLARK EDWARD A.;RYAN ELIZABETH;MARSHALL AARON;DRAVES KEVIN;UNIVERSITY OF WASHINGTON

发明人：CLARK EDWARD A.;RYAN ELIZABETH;MARSHALL AARON;DRAVES KEVIN

分类号：A61K39/395;A61K39/00

主分类号：A61K39/395

摘要：The invention provides novel dendritic cell-associated lectin-like (DCAL-1) molecules, compositions and therapeutic methods of use. In one aspect, the invention provides isolated nucleic acid molecules that are capable of remaining hybridized to SEQ ID NO:1 or SEQ ID NO:3, including nucleic acid molecules that encode DCAL-1 polypeptides. In another aspect, the invention provides DCAL-1 polypeptides and portions thereof which are useful to stimulate T cell proliferation. In another aspect, the invention provides antibodies that specifically bind to DCAL-1 which are useful for promoting maturation of dendritic cells and for stimulating an immune response in vivo. In another aspect the invention provides methods of stimulating an immune response in an animal comprising introducing into the animal an anti-DCAL-1 antibody of the invention.