Liposome preparation,申请号US20050594427-传众专利搜索

Liposome preparation

申请公布号：US8241663(B2)

申请号：US20050594427

申请日期：2005.03.25

申请公布日期：2012.08.14

申请人：

ISOZAKI MASASHI;YOSHINO KEISUKE;TAGUCHI KYOKO;KONDO MASAYO;TERUMO KABUSHIKI KAISHA

发明人：ISOZAKI MASASHI;YOSHINO KEISUKE;TAGUCHI KYOKO;KONDO MASAYO

分类号：A61K9/127;A61K31/704;A61K47/14;A61K47/24;A61K47/28;A61K47/30;A61K47/34;A61P35/00;G01N33/53

主分类号：A61K9/127

摘要：A liposome preparation is provided. This liposome preparation is capable of stably encapsulating a drug which is unstable under an acidic condition, and such stable encapsulation is realized without detracting the effect realized by the modification of the membrane by a hydrophilic macromolecule such as stability in blood. More specifically, the liposome preparation comprises a unilamellar vesicle formed from a lipid bilayer comprising a phospholipid as its main membrane component, and an interior aqueous phase of the vesicle at a pH of up to 5. The liposome has a drug loaded therein, and the vesicle is modified with a hydrophilic macromolecule only on its exterior surface.