METHODS FOR TREATING IMMUNE-MEDIATED DENGUE FEVER INFECTIONS AND ANTIBODY-DEPENDENT ENHANCEMENT OF DENGUE FEVER INFECTIONS, INCLUDING DENGUE HEMORRHAGIC FEVER AND DENGUE SHOCK SYNDROME,申请号EP20090798797-传众专利搜索

METHODS FOR TREATING IMMUNE-MEDIATED DENGUE FEVER INFECTIONS AND ANTIBODY-DEPENDENT ENHANCEMENT OF DENGUE FEVER INFECTIONS, INCLUDING DENGUE HEMORRHAGIC FEVER AND DENGUE SHOCK SYNDROME

申请公布号：EP2320924(A4)

申请号：EP20090798797

申请日期：2009.07.17

申请公布日期：2012.07.25

申请人：

TRINITY THERAPEUTICS, INC.

发明人：BODIE, NEIL, M.

分类号：A61K38/10;A61P31/12;A61P37/00

主分类号：A61K38/10

摘要：Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, as well as methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation in viral infection, are described. For example, polypeptides and other compounds can be used to inhibit binding of DF-associated, immune-complexed IgG anti-DF viron(s) or DV viral antigens to FγR, ADE of DF/DHF/DSS infections by inhibition of DF viral antigen binding to immune complexed IgG, FγR and immune complexed IgG mC1q (membrane C1q) or soluble C1q binding.