PROCESS FOR THE PRODUCTION OF 2-[4-(3- AND 2-FLUOROBENZYLOXY) BENZYLAMINO] PROPANAMIDES,申请号US201113288891-传众专利搜索

PROCESS FOR THE PRODUCTION OF 2-[4-(3- AND 2-FLUOROBENZYLOXY) BENZYLAMINO] PROPANAMIDES

申请公布号：US2012157712(A1)

申请号：US201113288891

申请日期：2011.11.03

申请公布日期：2012.06.21

申请人：

BARBANTI ELENA;CACCIA CARLA;SALVATI PATRICIA;VELARDI FRANCESCO;RUFFILLI TIZIANO;BOGOGNA LUIGI;NEWRON PHARMACEUTICALS S.P.A.

发明人：BARBANTI ELENA;CACCIA CARLA;SALVATI PATRICIA;VELARDI FRANCESCO;RUFFILLI TIZIANO;BOGOGNA LUIGI

分类号：C07C231/12

主分类号：C07C231/12

摘要：A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]propanamides and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight. The process is carried out by submitting the Schiff bases intermediates 2-[4-(3- and 2-fluorobenzyloxy)benzylideneamino]propanamides to catalytic hydrogenation in the presence of a heterogeneous catalyst in a protic organic solvent.