新颖咪唑衍生物

申请公布号：TWI357814

申请号：TW097124782

申请日期：2008.07.01

申请公布日期：2012.02.11

申请人：

赫孚孟拉罗股份公司 瑞士

发明人：乔汉斯　艾比;艾佛瑞　宾杰利;路克　葛林;基多　哈特曼;汉斯Ｐ　麦瑞奇;派崔吉欧　麦提;法比恩　瑞可林;奥利佛　罗契

分类号：A61K31/4178;A61K31/4523;A61K31/506;C07D403/06;C07D401/14;A61P9/10;A61P3/10;A61P11/06;A61P1/00

主分类号：A61K31/4178

代理人：陈长文 台北市松山区敦化北路201号7楼

地址：瑞士

摘要：本发明系关于新颖之式(I)咪唑衍生物，其中　、m、E、R1、R2、R3、R4、R5、R6及R7系如说明书及申请专利范围中所定义，以及其生理学上可接受之盐。此等化合物为CCR－2受体、CCR－5受体及/或CCR－3受体之拮抗剂且可用作药物。

TONOR SUPPLY APPARATUS FOR LASER BEAM PRINTER

VOTAGE LEVEL DISPLAY CIRCUIT

OVER SHOES

GAAS DEVICE FABRICATION AND DEVICES SO PRODUCED

NOVELTY CARD VENDING MACHINE

LIQUID PURIFICATION SYSTEMS AND METHODS

PAGER

METHOD AND APPARATUS FOR INCREMENTALLY STRETCHING A ZERO STRAIN STRETCH LAMINATE WEB TO IMPART ELASTICITY THERETO

COMPOSITE, PRESTRESSED STRUCTURAL MEMBER AND METHOD OF FORMING SAME

WIRELESS TELECOMMUNICATION SYSTEMS

PROCESS FOR PREPARING PYRIDINE DERIVATIVES

HOUSING DOOR LOCK AND CASSETTE PRESENCE DETECTOR OF VIDEO TAPE RECORDER

PROCESS FOR PREPARING A SUBSTANCE IN LIQUID FORM CAPABLE OF POLYMERMIZING BY FREE-RADICAL POLYMERIZATION,HAVING LOW SHRINKAGE FACTOR AND SUITABLE FOR PRODUCING THERMALLY STABLE ORGANIC GLASSES

PAVEMENT MARKERS WITH SILICONE ADHESIVE

AUTOMATIC EXHAUST TRAY APPARATUS FOR COPYING MACHINE

CIRCULAR SAW ARRANGEMENT

STRUCTURAL CONNECTOR APPROXIMATING A CONE OF ELLIPTICAL CROSS-SECTION

MAGNETO-OPTICAL RECORDING MEDIUM

USE OF CUCURBITIN FOR THE PREPARATION OF A COSMETIC OR PHARMACEUTICAL, PARTICULARLY DERMATOLOGICAL, ANTIALLERGENIC COMPOSITION AND METHOD INVOLVING APPLICATION THEREOF

PYRANYLPHENYL HYDROXYALKYLNAPHTHOIC ACIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS