BIOCOMPATIBLE OLIGOMER-POLYMER COMPOSITIONS
申请公布号:US2011245172(A1)
申请号:US20090995910
申请日期:2009.06.03
申请公布日期:2011.10.06
发明人:NORTON RICHARD L.
分类号:A61K47/30;A61K31/135;A61K31/215;A61K31/382;A61K31/4353;A61K31/498;A61K31/519;A61K31/542;A61K38/09;A61K38/31;A61P1/00;A61P5/00;A61P7/10;A61P9/00;A61P25/00;A61P31/00;A61P37/02;A61P37/06
主分类号:A61K47/30
摘要:The present invention relates to biocompatible oligomer-polymer compositions for the in situ formation of implants, wherein the implants release a bioactive agent, a metabolite, or a prodrug thereof, at a controlled rate. The sustained release delivery system includes a flowable composition containing a bioactive agent, a metabolite, or a prodrug thereof, and an implant containing a bioactive agent, a metabolite, or a prodrug thereof. The flowable composition may be injected into tissue whereupon it coagulates to become the solid or gel, monolithic implant. The flowable composition includes a biodegradable, thermoplastic polymer, a biocompatible end-capped oligomeric liquid, and a bioactive agent, a metabolite, or a prodrug thereof.