LIGHT-STABILIZED PHARMACEUTICAL COMPOSITION

申请公布号：EP2343078(A1)

申请号：EP20090817803

申请日期：2009.09.30

申请公布日期：2011.07.13

申请人：

DENKI KAGAKU KOGYO KABUSHIKI KAISHA

发明人：TAKAHASHI, KOICHI;MORIKAWA, TADASHI;YAMAZAKI, TADAO;SHIBATA, MASAKI

分类号：A61K31/728;A61K9/00;A61K9/08;A61K31/519;A61K45/06;A61K47/02;A61K47/12;A61K47/14;A61K47/18;A61K47/20;A61K47/22;A61K47/48;A61P19/02;A61P25/00

主分类号：A61K31/728

摘要：<p>A crosslinking reaction and a reaction for reducing molecular weight that take place in a hyaluronic acid-methotrexate conjugate upon irradiation with light are suppressed to improve the photostability of the conjugate. Specifically, a substance having a quenching effect and/or a radical scaveng effect is added to a pharmaceutical composition containing the hyaluronic acid-methotrexate conjugate.</p>

FISHING LEADER

AUTOMATIC SHOTGUN CHOKE

COMPOSITE WIRE DRAWING DIE

COORDINATED STOPPING OF TAKE-UP AND PROCESS MACHINES

METHOD FOR DEHYDRATION OF WET GASES

SHARPENING MECHANISM PARTICULARLY IN COMBINATION WITH A FORAGE CHOPPER OR THE LIKE

INK DRYING REFLECTOR SYSTEM

NAVIGATIONAL APPARATUS

TUBULAR KEY DECODER

METHOD FOR MAKING SELF-CENTERING PULLEYS

SLIDE FASTENER CHAIN

PROCESS FOR HEAT TREATING MULTI-COMPONENT YARNS

ROLLING PIN

LIMITED SLIP DIFFERENTIAL

DIFFERENTIAL TRANSMISSION

AUTOMATIC HEATING DEVICE TO PREVENT FREEZING OF WATER SUPPLY LINES

OBJECT IDENTIFYING APPARATUS

IMAGE DIVIDING MECHANISM IN PHOTOGRAPHIC CAMERAS FOR UNPERFORATED ROLLFILM

ENVIRONMENT MONITORING DEVICE AND SYSTEM

LUNAR SHELTER