PROCESS FOR THE PREPARATION OF IODINATED CONTRAST AGENT.,申请号MX20110005236-传众专利搜索

PROCESS FOR THE PREPARATION OF IODINATED CONTRAST AGENT.

申请公布号：MX2011005236(A)

申请号：MX20110005236

申请日期：2009.11.02

申请公布日期：2011.06.16

申请人：

BRACCO IMAGING S.P.A.

发明人：SILVIA CERAGIOLI;GIOVANNI CIARCIELLO;SALVATORE INCANDELA;PIETRO MINOTTI

分类号：C07C231/02

主分类号：C07C231/02

摘要：<p>The present invention relies on a process for the preparation of non ionic iodinated contrast agents and, in more details, it relates to a process for the preparation of Iopamidol in high yields and with a high degree of purity. In more details, the invention discloses a process for the preparation of a compound of formula (III) comprising the 5 condensation reaction a compound of formula (II) with 2-amino-1,3-propandiol, being said reaction carried out in an aprotic dipolar solvent and in the presence of an alkaline or alkaline rare earth metal oxide or hydroxide.</p>