TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

申请公布号：CA2483752(C)

申请号：CA20032483752

申请日期：2003.04.25

申请公布日期：2011.03.29

申请人：

MERCK & CO., INC.;MERCK SHARP & DOHME LIMITED

发明人：JIAO, RICHARD;MORRIELLO, GREGORI;YANG, LIHU;GOBLE, STEPHEN D.;MILLS, SANDER G.;PASTERNAK, ALEXANDER;ZHOU, CHANGYOU;BUTORA, GABOR;KOTHANDARAMAN, SHANKARAN;GUIADEEN, DEODIALSINGH;TANG, CHENG;MOYES, CHRISTOPHER

分类号：C07D471/04;A61K31/4375;A61K31/4745;A61P29/00;A61P37/02;C07D471/02;C07D519/00

主分类号：C07D471/04

摘要：The present invention is directed to compounds of the formula (I): (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

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