Benzylpiperazine derivates and their use in treating conditions mediated by GPR38 receptors
申请公布号:NZ565062(A)
申请号:NZ20060565062
申请日期:2006.07.24
申请公布日期:2011.02.25
发明人:JOHNSON, CHRISTOPHER NORBERT;MACPHERSON, DAVID TIMOTHY;STANWAY, STEVEN JAMES;STEMP, GEOFFREY;THOMPSON, MERVYN;WESTAWAY, SUSAN MARIE
分类号:C07D401/10;A61K31/496;A61P1/08
主分类号:C07D401/10
摘要:Disclosed is a compound including a piperidine and a piperazine as shown in formula (I), or a salt thereof, wherein A is phenyl or pyridine, and the other substituents are as defined in the specification. Also disclosed is the use of the compound to treat conditions mediated by GPR38 receptors, such as gastroesophageal reflux disorders, functional dyspepsia, irritable bowel syndrome, constipation, intestinal pseudo-obstruction, paralytic ileus following surgery or other manipulation, emesis, gastric stasis or hypomotility caused by various diseases such as diabetes and/ or by the administration of other drugs, Crohn's disease, colitis, cachexia associated with advanced diseases such as cancer and/or the treatment thereof, appetite/metabolism related cachexia, and incontinence. Also disclosed is a method to synthesise the compound, and intermediates useful in that method.
CONTENEDOR PLEGABLE PARA TRANSPORTAR UN LIQUIDO.
LINEA DE ARROLLAMIENTO PARA MATERIAL LAMINADO.
SISTEMA DE ILUMINACION DE EXTREMO LUMINOSO.
PROCEDIMIENTOS Y COMPOSICIONES PARA LA PRODUCCION DE LENTES OFTALMICAS TEÑIDAS.
AGUJA CON LONGITUD DE INYECCION AJUSTABLE PARA JERINGA EN FORMA DE BOLIGRAFO.
APARATO DE LIMPIEZA QUE INCLUYE UN DISPOSITIVO VIBRADOR.
PROCEDIMIENTO Y DISPOSITIVO PARA ESTERILIZAR MATERIAL DE ENVASADO.
PROCEDIMIENTO PARA PRODUCIR POLI(TEREFTALATO DE TRIMETILENO) (PTT).
APARATO ELECTRODOMESTICO PORTATIL.
METODO PARA EVALUAR EL TRATAMIENTO TERMICO AL CUAL SE SOMETE UN ALIMENTO PROTEICO TAL COMO LA LECHE.
COMPOSICION FARMACEUTICA QUE CONTIENE POLVOS DE PROLIPOSOMAS, DESTINADA A LA INHALACION.
MICROCAPSULAS PARA LA LIBERACION PROLONGADA DE FARMACOS.