NOVEL UBIQUITIN LIGASE AND USE THEREOF
申请公布号:WO2011016540(A1)
申请号:WO2010JP63345
申请日期:2010.08.06
申请公布日期:2011.02.10
发明人:IWAI, KAZUHIRO
分类号:C12N15/09;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/00;C12Q1/25
主分类号:C12N15/09
摘要:Disclosed is a novel ubiquitin ligase which has an activity of forming a linear polyubiquitin chain and can be expressed and purified with high efficiency. Specifically disclosed is a complex of (a) a protein comprising a part of HOIP and containing at least a UBA region and a RING-IBR-RING region and (b) at least one protein capable of forming a complex with the component (a). It is found that the complex is a novel ubiquitin ligase which has an activity of forming a linear polyubiquitin chain and can be expressed and purified with high efficiency.
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