COMPOUND USEFUL AS INHIBITOR OF JAK AND OTHER PROTEIN KINASE,申请号JP20100139840-传众专利搜索

COMPOUND USEFUL AS INHIBITOR OF JAK AND OTHER PROTEIN KINASE

申请公布号：JP2010195838(A)

申请号：JP20100139840

申请日期：2010.06.18

申请公布日期：2010.09.09

申请人：

VERTEX PHARMACEUT INC

发明人：BETHIEL RANDY S;MOON YOUNG CHOON

分类号：C07D213/74;A61K31/4418;A61K31/505;A61K31/506;A61K31/5377;A61P19/02;A61P21/02;A61P25/00;A61P25/28;A61P29/00;A61P35/00;A61P35/02;A61P37/02;A61P37/08;C07D239/42;C07D403/10;C07D405/12

主分类号：C07D213/74

摘要：<P>PROBLEM TO BE SOLVED: To develop an inhibitor of JAK, JNK, GSK, SYK, and CDK protein kinases. Ž<P>SOLUTION: The invention provides a compound of formula I or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions containing the compound and a method for utilizing the compounds and the compositions in the treatment of various protein kinase-mediated disorders. The compounds and its pharmaceutically acceptable compositions are effective as inhibitors of JAK-3, JNK-3, CDK-2, SYK, and GSK-3 protein kinases. The composition contains the compound of formula I, and a pharmaceutically acceptable carrier, adjuvant or vehicle. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž