T-bet compositions and methods of use thereof,申请号US20080070856-传众专利搜索

T-bet compositions and methods of use thereof

申请公布号：US7745581(B2)

申请号：US20080070856

申请日期：2008.02.21

申请公布日期：2010.06.29

申请人：

PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人：GLIMCHER LAURIE H.;SZABO SUSANNE J.

分类号：A01K67/027;C07K14/00;A61K31/7088;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P31/12;A61P35/00;C07K14/47;C07K14/725;C07K17/00;C12N5/10;C12N15/09;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/68;G01N33/74

主分类号：A01K67/027

摘要：Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a T-bet transgene. The invention further provides T-bet fusion proteins and anti-T-bet antibodies. Methods of using the T-bet compositions of the invention are also disclosed, including methods for detecting T-bet activity in a biological sample, methods of modulating T-bet activity in a cell, and methods for identifying agents that modulate the activity of T-bet.