TACROLIMUS FORMULATION WITH ENHANCED BIOAVAILABILITY AND METHOD FOR MANUFACTURING THE SAME,申请号KR20080119500-传众专利搜索

TACROLIMUS FORMULATION WITH ENHANCED BIOAVAILABILITY AND METHOD FOR MANUFACTURING THE SAME

申请公布号：KR20100060766(A)

申请号：KR20080119500

申请日期：2008.11.28

申请公布日期：2010.06.07

申请人：

SAMYANG CORPORATION

发明人：KIM, KYUNG HEE;CHOI, EUN JIN;PAI, CHAL MIN

分类号：A61K9/16;A61K31/44

主分类号：A61K9/16

摘要：PURPOSE: A tacrolimus formulation and a method for manufacturing the same are provided to quickly increase solubility and bioavailability of tacrolimus. CONSTITUTION: A tacrolimus microparticle contains a solid particulate substrate and tacrolimus layer in which tacrolimus is dispersed in a soluble polymer carrier. The carrier is hydroxypropyl methylceullose(HPMC), polyvinylpirrolydone(PVP), cellulose polymer or mixture thereof. The solid particlulate substrate is beads, spheres, cores, seeds, particles, or nuclei. The tacrolimus microparticle is obtained by dissolving HPMC and tacrolimus in mixture solvent of organic solvent and water. An oral formulation contains the tacrolimus microparticle. The oral formulation is a capsule or tablet.