Kinuklidyl-N-fenyl-N-alkylkarbamater og anvendelse derav ved fremstilling av medikamenter,申请号NO20020006211-传众专利搜索

Kinuklidyl-N-fenyl-N-alkylkarbamater og anvendelse derav ved fremstilling av medikamenter

申请公布号：NO328499(B1)

申请号：NO20020006211

申请日期：2002.12.23

申请公布日期：2010.03.01

申请人：

LABORATORIOS SALV AT SA

发明人：GARCIA ANDRES FERNANDEZ;BONO IGNACIO JOSE MIQUEL;ARNAL CARMEN LAGUNAS;GALLEMI CARLES FARRERONS;RUIZ JUAN LORENZO CATENA;SERRAT ANNA FERNANDEZ;LOPEZ DOLORS BALSA;NAVARRO JOSE IGNACIO BONILLA;ROCA CAROLINA SALCEDO

分类号：C07D453/02;A61K31/439;A61P1/00;A61P11/00;A61P11/02;A61P13/00;A61P13/10;A61P27/02;A61P43/00

主分类号：C07D453/02

摘要：The invention relates to carbamates having general structure (I), wherein: R1, R2 and R3 are H, OH, SH, CN, F, Cl, Br, I, (C1-C4)-alkylthio, (C1-C4)-alkoxyl, (C1-C4)-alkoxyl substituted by one or several F radicals, carbamoylamine, (C1-C4)-alkyl and (C1-C4)-alkyl substituted by one or several F or OH radicals; R4 represents a substituted or non-substituted cycloalkyl or cycloaryl radical (a heteroalkyl radical or not). The amine of the quinuclidine ring can also be forming quaternary ammonium salts or in an oxidized state (N-oxide). Carbamates (I) are antagonists of the M3 muscarinic receptor, and selectively, the M2 receptor. Hence, they can be used in the treatment of urinary incontinence (particularly due to bladder instability), irritable bowel syndrome, diseases of the respiratory tract (particularly chronic obstructive pulmonary disease, chronic bronchitis, asthma, emphysema and rhinitis) and in ophthalmologic operations.