TOSYLATE SALT OF TRANS-N-ISOBUTYL-3-FLUORO-3- [3-FLU0R0-4- (PYRROLIDIN-1-YL-METHYL) -PHENYL] CYCLOBUT ANECARBOXAMIDE,申请号WO2008IB03392-传众专利搜索

TOSYLATE SALT OF TRANS-N-ISOBUTYL-3-FLUORO-3- [3-FLU0R0-4- (PYRROLIDIN-1-YL-METHYL) -PHENYL] CYCLOBUT ANECARBOXAMIDE

申请公布号：WO2009071988(A1)

申请号：WO2008IB03392

申请日期：2008.12.04

申请公布日期：2009.06.11

申请人：

PFIZER INC.;WAGER, TRAVIS, T.;BUTLER, TODD, WILLIAM

发明人：WAGER, TRAVIS, T.;BUTLER, TODD, WILLIAM

分类号：C07D295/073;A61K31/40;A61P1/00;A61P11/00;A61P25/00

主分类号：C07D295/073

摘要：<p>The present invention is directed to the tosylate salt of trans-N-isobutyl- 3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)-phenyl]-cyclobutanecarboxamide Formula (1): to solvates (e.g., hydrates) thereof, to polymorphs thereof, to pharmaceutical compositions thereof and to a method of treating depression, mood disorders, schizophrenia, anxiety disorders, cognitive disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the Gl tract, hyper- and hypo-motility and acidic secretion of the gastro-intestinal tract comprising administering a therapeutically effective amount thereof.</p>