INTERLEUKIN -13 BINDING PROTEINS

申请公布号：EP2064336(A2)

申请号：EP20070873427

申请日期：2007.09.07

申请公布日期：2009.06.03

申请人：

ABBOTT LABORATORIES

发明人：WU, CHENGBIN;DIXON, RICHARD, W.;BELK, JONATHAN, P.;YING, HUA;ARGIRIADI, MARIA, A.;CUFF, CAROLYN, A.;HINTON, PAUL, R.;KUMAR, SHANKAR;MELIM, TERRY, L.;CHEN, YAN

分类号：C07K16/24;A61K38/00;A61K39/395;A61K45/06;C07K14/47

主分类号：C07K16/24

摘要：The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.

SEMICONDUCTOR DEVICE AND MANUFACTURING METHOD OF THE SAME

CONNECTOR

QUERYING DATABASE WITH LIKENESS CRITERION

POWER CONVERSION DEVICE

COOLING SYSTEM AND NON-CONTACT POWER SUPPLY SYSTEM

TRANSPARENT FAILOVER

ELECTRODE, ELECTRODE MANUFACTURING METHOD AND BATTERY

CONTENT VIEWING SYSTEM USING HEAD MOUNTED DISPLAY

PUSH BUTTON BOX

ELECTRONIC APPARATUS

ON-VEHICLE DEVICE FOR RECORDING OPERATION INFORMATION

FINGER VEIN AUTHENTICATION DEVICE

MANUFACTURING METHOD OF EMBEDDED MAGNET TYPE ROTOR UNIT AND MAGNETIZATION DEVICE

STATOR CORE

SEALING SHEET FOR SOLAR CELL MODULE AND SOLAR CELL MODULE

SOLAR CELL ELEMENT, SOLAR CELL MODULE, AND MANUFACTURING METHOD OF SOLAR CELL ELEMENT

DEVICE MANAGEMENT SYSTEM AND METHOD

VEHICLE CONTROLLER AND PROGRAM

KLYSTRON

POSITIVE ELECTRODE MATERIAL FOR NONAQUEOUS ELECTROLYTE SECONDARY BATTERY AND METHOD OF PRODUCING THE SAME, AND NONAQUEOUS ELECTROLYTE SECONDARY BATTERY USING THE POSITIVE ELECTRODE MATERIAL