CALMODULIN-BINDING PEPTIDES THAT REDUCE CELL PROLIFERATION IN CANCER AND SMOOTH MUSCLE PROLIFERATION DISEASES

申请公布号：CA2697252(A1)

申请号：CA20082697252

申请日期：2008.08.19

申请公布日期：2009.02.26

申请人：

UNIVERSITY HEALTH NETWORK

发明人：HUSAIN, MANSOOR;CHOI, JAEHYUN

分类号：C07K14/47;A61K38/17;A61L31/16;A61P9/10;A61P35/00;C07K16/18;C12N9/12;C12N15/12

主分类号：C07K14/47

摘要：The invention relates to an isolated peptide comprising all or part of the amino acid sequence: GGAEFSARSR KRKANVTVFL QD (SEQ ID NO: 2), wherein the peptide reduces cell proliferation. The invention also includes variants, such as SEQ ID NO:3-5 and fragments of at least 5 amino acids of SEQ ID NO:2-5 that reduce cell proliferation. The peptides are useful for treating cancer and diseases characterized by smooth muscle proliferation, such as restenosis.

POSITIONING DEVICE

RADIOLOCATING METHOD AND APPARATUS

AXIAL FLOW TURBINE

IMAGE FORMING APPARATUS

SCANNING IMAGE-FORMING LENS AND OPTICAL SCANNER

IMAGE FORMING DEVICE

TIGHTLY FIXED NEAR-MAGNETIC FIELD PROBE

ELECTROPHOTOGRAPHIC PHOTORECEPTOR BODY AND ELECTROPHOTOGRAPHIC DEVICE EQUIPPED WITH THE ELECTROPHOTOGRAPHIC PHOTORECEPTOR BODY

HOLDER FOR SPUTTERING OF OPTICAL DISK SUBSTRATE AND SPUTTERING METHOD

EXHAUST MUFFLER

CONTROL MEANS FOR VOICE REGENERATING DEVICE