N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands,申请号US20080232399-传众专利搜索

N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands

申请公布号：US2009018183(A1)

申请号：US20080232399

申请日期：2008.09.17

申请公布日期：2009.01.15

申请人：

ACTION PHARMA A/S

发明人：LUNDSTEDT TORBJORN;SKOTTNER ANNA;BOMAN ARNE;ANDERSSON PER;SEIFERT ELISABETH;ANDRIANOV VICTOR

分类号：A61K31/40;A61K31/5377;A61P1/14;A61P3/00;A61P3/04;A61P3/10;A61P5/00;A61P7/00;A61P9/00;A61P15/00;A61P17/16;A61P25/00;A61P25/02;A61P25/04;A61P25/28;A61P29/00;A61P35/00;A61P35/04;A61P37/08;C07D207/32;C07D207/335;C07D207/34;C07D207/36;C07D207/38;C07D207/42

主分类号：A61K31/40

摘要：The present invention provides novel compounds of the general Formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is (CH2)n where n is 0, 1 or 2; R1, R2, R3, R4 and R5 may be the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, alkylsulphonyloxy, cyano, nitro, trihaloalkyl, sulpho or one of the structures given in Scheme 1; or two of R1, R2, R3, R4 and R5 may together form a methylenedioxy or ethylenedioxy moiety; R6, R7, R8 and R9 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, alkoxy having 1 to 5 carbon atoms, hydroxy, amines (primary, secondary or tertiary) having 0, 1 or 2 carbon atoms, cyano, nitro, trihaloalkyl, amide or sulpho, and z where shown represents the point of attachment of the residue to the phenyl or pyrrole ring; and the pharmacologically active salts thereof.