MODULATION OF FR-ALPHA EXPRESSION

申请公布号：US2008167265(A1)

申请号：US20080971027

申请日期：2008.01.08

申请公布日期：2008.07.10

申请人：

ISIS PHARMACEUTICALS INC

发明人：FREIER SUSAN M.

分类号：A61K31/70;C07H21/04;C12N5/00;C12Q1/68

主分类号：A61K31/70

摘要：Disclosed herein are compounds, compositions and methods for modulating the expression of FR-alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.

SUBSTRATES AND METHOD FOR DETERMINING PROTEOLYTIC ENZYMES

Protective rim piece for a hole-in-sleeve of a wind-surf board mast and sleeve provided with such a piece.

Shaving apparatus.

Synchronous rotating assemblies for luminous scenographies with central part supporting four turning caps in orthogonal position.

Process and apparatus for continuously casting hollow products employing a magnetic field.

System for the transmission of messages to a subscriber's set through a subscriber's line in a telephone installation.

Device for treating the eyes with a bathing liquid.

Rinsing device for a catheter.

Grinding wheel and method for dressing the same.

Temporary lead with insertion tool.

Interferometric contact-free method for testing workpieces using ultrasonic wave vibrations.

Monolithic fast Fourier transform circuit.

Plasma monitoring method and plasma monitor.

Collimator with adjustable aperture.

Dimers of peptide amides.

Flame resistant resin composition.

Pneumatic timer.

Electromagnetic wave-shielding materials.

Double acting thrust ring for a toothed gearing with parallel axes.

Method of manufacturing poly-V pulleys and the products.