IDENTIFICATION OF COMPOUNDS MODIFYING A CELLULAR RESPONSE,申请号EP20050744449-传众专利搜索

IDENTIFICATION OF COMPOUNDS MODIFYING A CELLULAR RESPONSE

申请公布号：EP1759212(B1)

申请号：EP20050744449

申请日期：2005.05.25

申请公布日期：2008.12.17

申请人：

2CUREX

发明人：HAGEL, GRITH;THASTRUP, OLE;MELDAL, MORTEN;NORRILD, JENS, CHR.;HENTZER, MORTEN

分类号：G01N33/68;C07K1/04;C07K5/00;C07K5/103;C07K7/00;C07K7/06;C07K7/08;G01N33/50;G01N33/543;G01N35/00

主分类号：G01N33/68

摘要：<p>The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. The test compounds are linked to the solid support via cleavable linkers and may thus be released from the solid supports. Solid supports comprising cells, wherein the cellular response of interest has been modulated are selected and the test compound of the solid support can then be identified. The cellular response may for example be changes in complex formation between proteins.</p>