ASSESSMENT OF OOCYTE COMPETENCE,申请号WO2007US23216-传众专利搜索

ASSESSMENT OF OOCYTE COMPETENCE

申请公布号：WO2008066655(A3)

申请号：WO2007US23216

申请日期：2007.11.02

申请公布日期：2008.11.27

申请人：

YALE UNIVERSITY;WELLS, DAGAN;PATRIZIO, PASQUALE

发明人：WELLS, DAGAN;PATRIZIO, PASQUALE

分类号：C12Q1/68

主分类号：C12Q1/68

摘要：Methods are provided for evaluating an oocyte for fertilization and implantation. For example, methods are provided for determining whether an oocyte expresses, or does not express, one or more of a group of markers identified as differently expressed between chromosomally normal and chromosomally abnormal oocytes. Also provided, for example, are methods for determining whether a cumulus cell expresses, or does not express, one or more of a group of markers identified as differently expressed between cumulus cells associated with chromosomally normal oocytes and cumulus cells associated with chromosomally abnormal oocytes. Methods are provided for the detection of marker expression of differentially expressed genes at the RNA level, as well as at the protein level.