von Willebrand Factor (vWF)-cleaving protease,申请号EP20080156811-传众专利搜索

von Willebrand Factor (vWF)-cleaving protease

申请公布号：EP1956093(A1)

申请号：EP20080156811

申请日期：2002.04.25

申请公布日期：2008.08.13

申请人：

JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE

发明人：SOEJIMA, KENJI;MIMURA, NORIKO;MAEDA, HIROAKI;NOZAKI, CHIKATERU;HAMAMOTO, TAKAYOSHI;NAKAGAKI, TOMOHIRO

分类号：A61K38/00;A01K67/027;C12N15/57;A61K31/711;A61K38/46;A61K39/395;A61K45/00;A61K48/00;A61P1/16;A61P7/02;A61P9/04;A61P9/10;A61P43/00;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/50;C12N9/64;C12N15/09;C12P21/00;C12Q1/37

主分类号：A61K38/00

摘要：<p>This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val as a partial sequence, and more preferably comprises a polypeptide chain having the partial N-terminal amino acid sequence of a mature protein, Ala-Ala-Gly-Gly-He-Leu-His-Leu-Glu-Leu-Leu-Val-Ala-Val, and having a molecular weight of 105 to 160 kDa in SDS-PAGE under reducing or non-reducing conditions. Isolation and identification of this vWF-specific cleaving protease have led to the possibility of replacement therapy for patients having diseases resulting from a deficiency of the protease, such as thrombotic thrombocytopenic purpura.</p>