Immobilization of biological molecules onto surfaces coated with monolayers,申请号AU20020329864-传众专利搜索

Immobilization of biological molecules onto surfaces coated with monolayers

申请公布号：AU2002329864(B2)

申请号：AU20020329864

申请日期：2002.08.27

申请公布日期：2008.07.31

申请人：

SURFACE LOGIX, INC.

发明人：EVELYN WANG;CHRISTIAN HODNELAND;STEWART CAMPBELL;MELINA AGOSTO;DAVID DUFFY

分类号：G01N33/53;C07B61/00;C07D207/452;C07K1/107;C07K17/14;C12M1/40;C12N9/16;C12N9/18;C12N11/14;C12N15/09;C23C26/00;G01N27/327;G01N27/48;G01N33/543;G01N33/547;G01N33/553

主分类号：G01N33/53

摘要：The present invention provides an article for immobilizing functional organic biomolecules through a covalent bond to a thiolate monolayer on a coinage metal surface. Also provided are methods for making the article and method for the immobilization of functional organic biomolecules on the article. The thiolate monolayer contains two moieties, one having an inert group that is resistant to reacting with biomolecules and one having a covalent bond forming group that reacts with the functional organic biomolecule to covalently immobilize it on the monolayer.