CANCER CHEMOPREVENTION STRATEGY BASED ON LOSS OF IMPRINTING OF IGF2,申请号CA20072708006-传众专利搜索

CANCER CHEMOPREVENTION STRATEGY BASED ON LOSS OF IMPRINTING OF IGF2

申请公布号：CA2708006(A1)

申请号：CA20072708006

申请日期：2007.12.07

申请公布日期：2008.06.19

申请人：

THE JOHNS HOPKINS UNIVERSITY;THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SEC RETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人：FEINBERG, ANDREW P.;LEVCHENKO, ANDRE;LONGO, DAN L.;KO, MINORU S. H.

分类号：A61K39/395;A61K31/704

主分类号：A61K39/395

摘要：The present invention relates to targets of loss of imprinting (LOI) affected IGF2 gene products in pre-malignant tissues, where methods of inhibiting those targets, including IGFRl, are disclosed to prevent tumor development in subjects at risk for developing colorectal cancer (CRC). The present invention also relates to methods of identifying increased risk in developing CRC in a subject, including methods of assessing the efficacy of a chemotherapeutic regimen. Further, the present invention relates to methods for identifying anti-neoplastic agents.