Glipizide controlled-release composition and method of preparation

申请公布号：US2008102118(A1)

申请号：US20060634514

申请日期：2006.12.05

申请公布日期：2008.05.01

申请人：

OCEAN STAR INTERNATIONAL, INC.

发明人：GAN YONG;ZHOU XINTENG

分类号：A61K9/22

主分类号：A61K9/22

摘要：A glipizide controlled release composition is provided comprising a drug-layer and a push-layer at a ratio of 1:0.5~3 by weight. The drug-layer contains glipizide and 40~99 percent by weight of the drug-layer of hydrophilic polyvinylpyrrolidone homopolymer and/or copolymer carrier. The push-layer comprises about 10 to 80 percent by weight of the push-layer of osmopolymers, about 10 to 80 percent by weight of the push-layer of water-insoluble polymers, and about 5 to 50 percent by weight of the push-layer of osmagents. The composition is used in osmotic pump tablets for controlled release of glipizide useful for administration once a day.

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