PROCESS FOR PRODUCING (�)-trans-4-(4-FLUOROPHENYL)-3-HYDROXYMETHYLPIPERIDINE

申请公布号：JP2008050345(A)

申请号：JP20070187985

申请日期：2007.07.19

申请公布日期：2008.03.06

申请人：

SUMITOMO CHEMICAL CO LTD

发明人：KAWAMI KO;YAMADA SEIJI;ISHIHARA AKIRA

分类号：C07D211/22;C07B61/00

主分类号：C07D211/22

摘要：PROBLEM TO BE SOLVED: To provide a process by which (±)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine can simply and industrially be produced in good purity and good yield. SOLUTION: The process for producing the (±)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine is carried out as follows. (±)-trans-4-(4-Fluorophenyl)-3-methoxycarbonylpiperidin-6-one is reduced with a boron trifluoride-ether complex and sodium borohydride to provide a reaction solution. A mineral acid and a potassium salt are then added to the resultant reaction solution to regulate the pH to 0.5-4.0. Deposited materials are removed to afford an acidic solution. The pH of the resultant acidic solution is then regulated to 11.0-12.5. COPYRIGHT: (C)2008,JPO&INPIT

Temperature measuring device

Multiprinting thermal transfer ink ribbon cassette

Pipe joint assembly

Uncancelled turn signal indicator

Lock mechanism

Container for transporting long objects, especially rolls for papermaking machines

Restriction subs for setting cement plugs in wells

Blade assembly for planer cutter head

Downdraft barbecue

Apparatus for changing operation timing of valves for internal combustion engine

Method and device for controlling strain and/or deflection in superstructures

Printing cylinder with rubber coating for letterpress, flexography, rotogravure and rotary offset

Apertured valve disposed in hollow piston rod of follower-type motor

Socket wrench with improved handle

Key shift transmission

Linear displacement sampling valve and a device for fixing same

Liquid level indicating device

Catch device for a roll-up door, grate, grill or the like

Rock cutting tool

Housing of a distributor including an ignition coil for an internal combustion engine