Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood,申请号US20040794878-传众专利搜索

Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood

申请公布号：US7335383(B2)

申请号：US20040794878

申请日期：2004.03.05

申请公布日期：2008.02.26

申请人：

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人：MEYERHOFF MARK E.;REYNOLDS MELISSA M.;OH BONG K.

分类号：A61K33/34;A61F2/00;A61K38/44;A61M1/36;B01J23/72;B01J31/00;B01J31/18;C12N9/04;C12N11/00;C12N11/02;C12N11/08;C12N11/14

主分类号：A61K33/34

摘要：A material includes a surface and a reactive agent that is located at the surface of the material, covalently attached to a backbone of the material, and/or located within the material. The reactive agent has nitrite reductase activity, nitrate reductase activity, and/or nitrosothiol reductase activity. The reactive agent also converts at least one of nitrites, nitrates and nitrosothiols to nitric oxide when in contact with blood. A reproducible nitrosothiol sensor is also disclosed.