Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases,申请号EP20070090052-传众专利搜索

Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases

申请公布号：EP1834644(A3)

申请号：EP20070090052

申请日期：2004.05.27

申请公布日期：2007.11.07

申请人：

BAYER SCHERING PHARMA AKTIENGESELLSCHAFT

发明人：FUHRMANN, ULRIKE;HOFFMANN, JENS;SCHNEIDER, MARTIN;SIEMEISTER, GERHARD

分类号：A61K31/567;A61K45/06;A61P5/32;A61P5/36

主分类号：A61K31/567

摘要：<p>The present invention relates to methods and uses for preventing or treating hormone-dependent diseases, in particular breast cancer, in a mammal, by a combination of an progesterone-receptor antagonist, in particular the progesterone-receptor antagonist 11β-(4-acetylphenyl)-17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof, and a pure antiestrogen, in particular a compound of general formula I as defined in the specification, for instance 11β-Fluoro-17α-methyl-7α-{5-[methyl(8,8,9,9,9-pentafluorononyl)amino]pentyl}-estra-1,3,5(10)-triene-3,17β-diol. The invention further relates to pharmaceutical compositions comprising said combination.</p>