Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes

申请公布号：US2007232676(A1)

申请号：US20070728673

申请日期：2007.03.27

申请公布日期：2007.10.04

申请人：

BIFTU TESFAYE;WEBER ANN E

发明人：BIFTU TESFAYE;WEBER ANN E.

分类号：A01N43/56

主分类号：A01N43/56

摘要：The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

SCANNING OPTICAL DEVICE

REINFORCED STRUCTURE OF OPTICAL FIBER TYPE COUPLER

APPARAT SOM KOMMUNISERER MED DATASYSTEMER, OG FREMGANGSMAATE TIL KOMMUNIKASJON MED DATASYSTEMER

Equine herpes viruses (EHV) containing foreign DNA, process for their preparation and their use as vaccines.

ELECTRODEPOSITION DEVICE

Sulfonylaminocarbonyltriazolinones with oxygen-bound substituents.

Containerization system

Carrier stock with tear-open tabs

New heterocycle-substituted alkylamides, process for¹preparing them and pharmaceutical compositions containing¹them

Fitment for a bottle, to prevent refilling

USE OF 4-AMINO-1-(2-PYRIDYL)PIPERIDINES FOR THE PREPARATION¹OF A MEDICAMENT FOR THE TREATMENT AND PROPHYLAXIS OF¹CONDITIONS DERIVING FROM DISORDERS OF THE SEROTONINERGIC¹SYSTEMS MEDIATED BY 5-HT RECEPTORS

Standardized step module for building prefabricated¹staircases, process for producing such module, prefabricated¹staircase and process for assembling prefabricated¹staircases

PROCESS FOR THE PREPARATION OF 1-TRIAZOLYLETHYL ETHERS AND NOVEL DERIVATIVES THEREOF

Apparatus for the communication between a central unit and several peripheral units.

LOWERING UNIT AREA PRESSURE.

AMINO ACID THIOHYDANTOIN METHOD AND REAGENT.

VALVE ASSEMBLY BODY

TECHNICAL FIBRE STRUCTURAL MEMBER SUBJECTED TO TENSILE STRESS.

LOSSLESS OPTICAL COMPONENT.

IMMUNOLOGICALLY ACTIVE PROTEINES FROM BORRELIA BURGDORFERI, RELATED TEST KITS AND VACCINE.