Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences,申请号US20070785701-传众专利搜索

Collapsin response mediator protein-1 (CRMP-1) transcriptional regulatory nucleic acid sequences

申请公布号：US2007224681(A1)

申请号：US20070785701

申请日期：2007.04.19

申请公布日期：2007.09.27

申请人：

YANG PAN-CHYR;HONG TSE-MING;CHEN JEREMY J;WU CHENG-CHUNG;SHIN JIN-YUAN

发明人：YANG PAN-CHYR;HONG TSE-MING;CHEN JEREMY J.;WU CHENG-CHUNG;SHIN JIN-YUAN

分类号：C12N15/63;A61K48/00;C07H21/04;C12N5/00;C12N5/08;C12N15/85;C12P33/10

主分类号：C12N15/63

摘要：This invention provides a transcription unit which is isolated from the upstream nucleic acid sequence of the collapsing response mediator protein-1 (CRMP-1) gene, an invasion-suppressor gene. The transcription unit contains a nucleic acid regulatory sequence which demonstrates promoter and/or regulatory activities (such as providing a transcription factor binding site) to enhance the expression of the CRMP-1 and/or a reporter protein. The invention also provides a DNA construct containing this transcription unit which can be transfected into a host cell. Additionally, the invention provides methods to enhance the expression of CRMP-1 and/or the reporter protein. The over-expression of CRMP-1 in a cancer cell can inhibit the metastasis of the cancer cell.