Production of polyketides and other natural products,申请号EP20050075774-传众专利搜索

Production of polyketides and other natural products

申请公布号：EP1589031(B1)

申请号：EP20050075774

申请日期：2003.07.16

申请公布日期：2007.08.15

申请人：

BIOTICA TECHNOLOGY LIMITED

发明人：GREGORY, MATTHEW ALAN;GAISSER, SABINE;PETKOVIC, HRVOJE;MOSS, STEVEN

分类号：C07K14/36;C12N15/09;A61K31/407;A61K31/436;A61K31/706;A61P31/10;A61P35/00;A61P37/04;C07D493/18;C07D498/18;C07H15/04;C12N1/21;C12N15/10;C12N15/52;C12N15/70;C12N15/76;C12P17/18;C12P19/62;C12R1/55

主分类号：C07K14/36

摘要：The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains). <IMAGE>