含有FGF2作为有效成分的治疗或预防哮喘和慢性阻塞性肺病的药剂

申请公布号：CN1953765A

申请号：CN200580015391.3

申请日期：2005.05.12

申请公布日期：2007.04.25

申请人：

东亚制药株式会社;金润根

发明人：金润根;姜寿亨;金炳文;孙美苑

分类号：A61K38/18(2006.01)

主分类号：A61K38/18(2006.01)

代理机构：

北京信慧永光知识产权代理有限责任公司

代理人：梁兴龙;王维玉

地址：韩国首尔市

摘要：本发明涉及一种含有FGF2(成纤维细胞生长因子－2或碱性成纤维细胞生长因子(bFGF))作为有效成分的、用于治疗或预防哮喘和慢性阻塞性肺病(COPD)的药剂。本发明还涉及由卵清蛋白和双链RNA诱发的Th1哮喘和COPD小鼠动物模型。本发明的含有FGF2的治疗药剂可用于治疗或预防气道纤维化、气道炎症、气道高反应性、气道重塑、哮喘和COPD。此外，由卵清蛋白和双链RNA诱发的Th1哮喘和COPD小鼠动物模型还可用于开发哮喘和COPD的治疗药剂。

主权项：1.一种含有FGF2(成纤维细胞生长因子-2)作为有效成分的治疗或预防哮喘的药剂。

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