Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof,申请号US20060410186-传众专利搜索

Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof

申请公布号：US2007020686(A1)

申请号：US20060410186

申请日期：2006.04.24

申请公布日期：2007.01.25

申请人：

THE ROCKEFELLER UNIVESITY

发明人：FRIEDMAN JEFFREY M.;LEE GWO-HWA;PROENCA RICARDO

分类号：G01N33/53;C07H21/04;C07K14/705;C07K16/28;C12N1/21;C12P21/06

主分类号：G01N33/53

摘要：The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.