Biarylmethyl indolines and indoles as antithromboembolic agents,申请号US20040824025-传众专利搜索

Biarylmethyl indolines and indoles as antithromboembolic agents

申请公布号：US7129264(B2)

申请号：US20040824025

申请日期：2004.04.14

申请公布日期：2006.10.31

申请人：

BRISTOL-MYERS SQUIBB COMPANY

发明人：SMALLHEER JOANNE M.;QUAN MIMI L.;WANG SHUAIGE;BISACCHI GREGORY S.

分类号：A61K31/404;A61K31/4045;A61K31/405;A61K31/4745;C07D;C07D209/04;C07D209/10;C07D209/14;C07D209/18;C07D471/02

主分类号：A61K31/404

摘要：The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or hydrate form thereof, wherein the variables A, B, L1, L2, X1, X2, X3, X4 and W are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.