MONOCLONAL ANTIBODIES THAT BIND OR NEUTRALIZE HEPATITIS B VIRUS,申请号WO2006US01336-传众专利搜索

MONOCLONAL ANTIBODIES THAT BIND OR NEUTRALIZE HEPATITIS B VIRUS

申请公布号：WO2006076640(A1)

申请号：WO2006US01336

申请日期：2006.01.13

申请公布日期：2006.07.20

申请人：

THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ASH AND HUMAN SERVICES REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALT;SCHOFIELD, DARREN, J.;EMERSON, SUZANNE, U.;PURCELL, ROBERT, H.

发明人：SCHOFIELD, DARREN, J.;EMERSON, SUZANNE, U.;PURCELL, ROBERT, H.

分类号：C07K16/08;A61K39/29;G01N33/576

主分类号：C07K16/08

摘要：The present invention relates to the isolation and characterization of a novel neutralizing chimpanzee monoclonal antibody to hepatitis B virus. The invention provides such antibodies, fragments of such antibodies retaining hepatitis B virus-binding ability, fully human or humanized antibodies retaining hepatitis B virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.