Quick disintegrating tablet in buccal cavity and manufacturing method thereof,申请号US20030667077-传众专利搜索

Quick disintegrating tablet in buccal cavity and manufacturing method thereof

申请公布号：US7074428(B2)

申请号：US20030667077

申请日期：2003.09.18

申请公布日期：2006.07.11

申请人：

ASTELLAS PHARMA INC.

发明人：KAJIYAMA ATUSHI;TAMURA TETSUYA;MIZUMOTO TAKAO;KAWAI HITOSHI;TAKAHASHI TATSUYA

分类号：A61K9/20;A61K9/00;A61K9/14;A61K9/16;A61K9/28

主分类号：A61K9/20

摘要：The present invention pertains to a quick disintegrating tablet in buccal cavity, characterized in that drug-containing particles with a mean particle diameter of approximately 50 to approximately 250 mum and an apparent specific gravity of approximately 0.5 to approximately 1.2 consisting of a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier and obtained by spray drying are added to a quick disintegrating tablet in buccal cavity comprising a drug and a saccharide. Moreover, the present invention pertains to a method for manufacturing drug-containing particles having a specific mean particle diameter and specific apparent gravity by dissolving and suspending a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier to a high concentration in terms of solid concentration in a solvent and spray drying this liquid and a method for manufacturing a quick disintegrating tablet in buccal cavity comprising the particles.