Stabilized ascorbic acid solutions; use thereof; process for their obtention; and formulations comprising the same,申请号US20030363929-传众专利搜索

Stabilized ascorbic acid solutions; use thereof; process for their obtention; and formulations comprising the same

申请公布号：US2006029687(A1)

申请号：US20030363929

申请日期：2003.03.07

申请公布日期：2006.02.09

申请人：

VIVIER GHISLAIN;COSTA ANTHONY

发明人：VIVIER GHISLAIN;COSTA ANTHONY

分类号：A61K9/08;A61K36/752;A61K8/00;A61K8/30;A61K8/33;A61K8/34;A61K8/35;A61K8/49;A61K8/67;A61K8/96;A61K8/97;A61K31/375;A61K36/73;A61K36/75;A61K47/08;A61K47/10;A61K47/14;A61K47/24;A61K47/46;A61P17/00;A61P17/04;A61P17/06;A61P17/10;A61P17/16;A61P35/00;A61P37/08;A61P39/06;A61Q17/04;A61Q19/00;A61Q19/08

主分类号：A61K9/08

摘要：This invention relates to improved solutions comprising ascorbic acid (vitamin C). These solutions may comprise as much as 15% ascorbic acid; they are stable for at least two years, without no significant development of yellowish coloration and no substantial (not more than 10%) degradation of the vitamin. The process involves sequential additions of ascorbic acid and ethoxydiglycol to a first solution of vitamin in water, which are followed by addition of propylene glycol. The high stirring speed that occurs during the additions favorises a process of micronisation. Mild heating is used to achieve ascorbic acid concentrations equivalent to about 6% in 10% water or higher.