Carboline derivatives useful in the treatment of cancer

申请公布号：US2005282849(A1)

申请号：US20050107783

申请日期：2005.04.18

申请公布日期：2005.12.22

申请人：

MOON YOUNG-CHOON;CAO LIANGXIAN;TAMILARASU NADARAJAN;QI HONGYAN;CHOI SOONGYU;LENNOX WILLIAM J;CORSON DONALD T;HWANG SEONGWOO;DAVIS THOMAS

发明人：MOON YOUNG-CHOON;CAO LIANGXIAN;TAMILARASU NADARAJAN;QI HONGYAN;CHOI SOONGYU;LENNOX WILLIAM J.;CORSON DONALD T.;HWANG SEONGWOO;DAVIS THOMAS

分类号：A61K31/4745;A61K31/724;(IPC1-7):A61K31/724;A61K31/474

主分类号：A61K31/4745

摘要：In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

METHOD FOR OBTAINING OF 8, 8- DISUBSTITUATED- 6- METHYLERGOLIN

PROCEDE ET INSTALLATION DE CUISSON, DECONGELATION OU REFROIDISSEMENT DE PRODUITS ALIMENTAIRES ET NOTAMMENT DE JAMBONS

APPARATUS FOR PREVENTION OF SIX PHASE THIRISTOR TRANSDUCER

PLIEUSE AUTOMATIQUE DE TOLES

PROCEDE POUR RECUPERER L'ENERGIE DU GAZ EN EXCES DE FOURS A SOUFFLERIE

PROCEDIMIENTO PARA OBTENER DERIVADOS DE 2-(N'-FENILHIDRAZINO)-1-PIRROLINA Y SUS SALES

COMPOSICIONES HERBICIDAS EN BASE A DIAMINO-2,4 CLORO-6 METIL-TIO-5 PIRIMIDINA Y DERIVADOS HERBICIDAS DE LA UREA

CIERRE DE EMERGENCIA DE TIPO ARIETE

CONJUNTO DE FILTRO PARA UNA COLUMNA DE TABACO

DISPOSITIVO PARA CAPTURAR CUCARACHAS

CUBA DE TRANSPORTE APROPIADA PARA EL TRANSPORTE DE MATERIALES A GRANEL CALIENTES,ESPECIALMENTE DE COQUE

PINZA MEJORADA PARA APLICAR PLACAS DE IDENTIFICACION A GANADOS

PERFECTIONNEMENTS AUX DISPOSITIFS ET PROCEDES POUR LA PURIFICATION DU SANG

NOUVEAUX DERIVES D'ALKYLENEDIAMINE, PROCEDE POUR LES PREPARER ET MEDICAMENTS LES CONTENANT

PROCEDE DE FABRICATION D'ESTERS DE L'ACIDE ACRYLIQUE OU METHACRYLIQUE

PROCEDE DE FABRICATION DE TUBES DE REVETEMENT EN UN ALLIAGE A BASE DE ZIRCONIUM POUR BARRES DE COMBUSTIBLE POUR REACTEURS NUCLEAIRES

PREPARATION THERAPEUTIQUE AYANT D'EXCELLENTES PROPRIETES D'ABSORPTION

PROCEDIMIENTO PARA LA PREPARACION DE CUERPOS MICROPOROSOS QUE EN GLOBEN UNO O MAS AGENTES ACTIVOS

CIRCUITO ELIMINADOR INHIBIBLE PARA UN RADIORRECEPTOR CONVENCIONAL

DISPOSITIVO PARA CAPTURAR CUCARACHAS