ALTERED FIBRONECTIN-BINDING PROTEIN OF STAPHYLOCOCCUS AUREUS,申请号CA20052562037-传众专利搜索

ALTERED FIBRONECTIN-BINDING PROTEIN OF STAPHYLOCOCCUS AUREUS

申请公布号：CA2562037(A1)

申请号：CA20052562037

申请日期：2005.05.17

申请公布日期：2005.12.08

申请人：

WYETH

发明人：BAKER, STEVEN MORRIS;ANDERSON, ELIZABETH TEREMY;MATSUKA, YURY VLADIMIROVICH

分类号：C07K14/31;A61K39/00;C07K14/315

主分类号：C07K14/31

摘要：An isolated, altered fibronectin-binding protein (Fnb) of S. aureus having a t least one mutation in an amino acid selected'from residues corresponding to GIn103, GIn105, Lys157, Lys503, Lys620, Lys702, Lys762, Gln783 and Gln830 of FnbA of S. aureus strain ATCC49525 is described. Replacement of these reacti ve residues within the fibronectin-binding protein renders this protein less capable than wild-type Fnb of covalently cross-linking with fibronectin and fibrin. The altered fibronectin~binding protein effectively interferes with adhesion of S. aureus to fibronectin and fibrin, and therefore, an immunogen ic composition comprising such altered Fnb exhibits improved immunogenic properties and is safer to use.