SUBSTITUTED INDOLES AS ALPHA-1 AGONISTS,申请号PL20030373410-传众专利搜索

SUBSTITUTED INDOLES AS ALPHA-1 AGONISTS

申请公布号：PL373410(A1)

申请号：PL20030373410

申请日期：2003.01.23

申请公布日期：2005.08.22

申请人：

F.HOFFMAN-LA ROCHE AG

发明人：GREENHOUSE ROBERT;JAIME-FIGUEROA SAUL;RAPTOVA LUBICA

分类号：C07D209/00;A61K31/4178;A61K31/506;A61K31/5377;A61P1/14;A61P7/12;A61P11/02;A61P13/00;A61P13/02;A61P15/10;A61P25/22;A61P25/24;A61P25/28;A61P27/16;A61P29/00;A61P43/00;C07D403/06;C07D495/04

主分类号：C07D209/00

摘要：This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I:wherein X is -S(O)n- or -C(O)-, A is C1-6alkyl, aryl, heteroaryl, hydroxyalkyl, or -(CH2)p-NR<a>R<b>, and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.