Drug delivery systems and use thereof,申请号US20040979785-传众专利搜索

Drug delivery systems and use thereof

申请公布号：US2005175708(A1)

申请号：US20040979785

申请日期：2004.11.02

申请公布日期：2005.08.11

申请人：

CARRASQUILLO KAREN G.;ADAMIS ANTHONY P.;MILLER JOAN W.;GRAGOUDAS EVANGELOS S.

发明人：CARRASQUILLO KAREN G.;ADAMIS ANTHONY P.;MILLER JOAN W.;GRAGOUDAS EVANGELOS S.

分类号：A61F2/00;A61F9/00;A61K9/00;A61K9/16;(IPC1-7):A61K9/14;A61K39/395;A61K31/701

主分类号：A61F2/00

摘要：The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to an eye for the treatment of an ocular disorder, for example, age-related macular degeneration.