Microbial n-and o-demethylation of a thebaine derivative,申请号US20040512746-传众专利搜索

Microbial n-and o-demethylation of a thebaine derivative

申请公布号：US2005164358(A1)

申请号：US20040512746

申请日期：2004.10.27

申请公布日期：2005.07.28

申请人：

CARNELL ANDREW J.;DAVIS JOHN A.

发明人：CARNELL ANDREW J.;DAVIS JOHN A.

分类号：C07D489/12;C12P17/18;(IPC1-7):C12P17/18;C12N1/16

主分类号：C07D489/12

摘要：The invention provides a process for the N-demethylation or the N- and O-demethylation of a thebaine derivative which process comprises fermenting the derivative with a biocatalyst selected from the filamentous fungi from Cunninghamella dalmatica NRRL 1394, Cunninghamella echinulata NRRL 1387, Cunninghamella echinulata NRRL 1384, Cunninghamella echinulata ATCC 36190, Cunninghamella echinulata ATCC 11585a, Cunninghamella echinulata ATCC 9244, Cunninghamella polymorpha NRRL 1395, or Rhizopus nigricans Z5/1 in a basal fermentation medium at a temperature of at least 25° C. and not more than 34° C., for a period of time of at least 3 days.