GENE DELIVERY MEDIATED BY LIPOSOME-DNA COMPLEX WITH CLEAVABLE PEG SURFACE MODIFICATION,申请号WO2004US41170-传众专利搜索

GENE DELIVERY MEDIATED BY LIPOSOME-DNA COMPLEX WITH CLEAVABLE PEG SURFACE MODIFICATION

申请公布号：WO2005051351(A3)

申请号：WO2004US41170

申请日期：2004.11.19

申请公布日期：2005.07.14

申请人：

ALZA CORPORATION;HUANG, SHI-KUN;ZALIPSKY, SAMUEL

发明人：HUANG, SHI-KUN;ZALIPSKY, SAMUEL

分类号：A61K9/127;A61K47/48;A61K48/00;C07F9/02;C12N15/88

主分类号：A61K9/127

摘要：A liposome composition and method for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a cationic lipid and (ii) a lipid joined to a hydrophilic polymer by a releasable linkage. The liposomes are associated with a nucleic acid for delivery to a cell.