Cyclic amp phosphodiesterase 4d7 isoforms and methods of use,申请号US20040492835-传众专利搜索

Cyclic amp phosphodiesterase 4d7 isoforms and methods of use

申请公布号：US2005132428(A1)

申请号：US20040492835

申请日期：2004.12.02

申请公布日期：2005.06.16

申请人：

WANG DAGUANG;XIN XIAONAN;UNTERBECK AXEL J.;LEONARD CHRISTOPHER J.;VIVO MICHAEL D.

发明人：WANG DAGUANG;XIN XIAONAN;UNTERBECK AXEL J.;LEONARD CHRISTOPHER J.;VIVO MICHAEL D.

分类号：A01K67/027;A61K31/519;A61K31/7088;A61K38/00;A61K38/46;A61K39/395;A61K45/00;A61K48/00;A61P1/00;A61P1/04;A61P3/10;A61P9/00;A61P9/08;A61P9/10;A61P11/00;A61P11/06;A61P11/08;A61P13/12;A61P17/00;A61P17/02;A61P17/04;A61P17/06;A61P17/08;A61P17/10;A61P17/12;A61P17/14;A61P17/16;A61P19/00;A61P19/02;A61P21/04;A61P25/00;A61P25/14;A61P25/16;A61P25/18;A61P25/24;A61P25/28;A61P25/36;A61P27/14;A61P27/16;A61P29/00;A61P35/00;A61P35/02;A61P37/02;A61P37/08;A61P43/00;C07H21/04;C07K16/40;C12N;C12N1/15;C12N1/19;C12N5/10;C12N9/16;C12N15/09;C12P21/08;C12Q1/02;C12Q1/44;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566;(IPC1-7):A01K67/027

主分类号：A01K67/027

摘要：Human, rat and mouse cAMP phosphodiesterase isoforms (denoted PDE4D7s), as well as the DNA (RNA) encoding such polypeptides, are disclosed. Also disclosed are methods for utilizing such polypeptides in diagnostic assays for identifying mutations in nucleic acid sequences encoding the polypeptides of the present invention, for detecting altered levels of the polypeptide of the present invention as a means of detecting diseases and methods of screening potential modulators, especially inhibitors, of the novel PDE4D7s disclosed herein. Such as inhibitors can be used, for example, as a means of increasing cyclic AMP in neurons and thus treating neurological problems, such as long term memory loss, if not preventing such maladies entirely. Transgenic animals expressing polypeptides disclosed herein are also described.