INJECTABLE MULTIMODAL POLYMER DEPOT COMPOSITIONS AND USES THEREOF,申请号EP20030771916-传众专利搜索

INJECTABLE MULTIMODAL POLYMER DEPOT COMPOSITIONS AND USES THEREOF

申请公布号：EP1539101(A2)

申请号：EP20030771916

申请日期：2003.07.28

申请公布日期：2005.06.15

申请人：

ALZA CORPORATION

发明人：CHEN, GUOHUA;HOUSTON, PAUL;KLEINER, LOTHAR;WRIGHT, JEREMY

分类号：A61K47/38;A61K9/00;A61K9/06;A61K9/10;A61K9/14;A61K9/20;A61K47/08;A61K47/10;A61K47/12;A61K47/14;A61K47/22;A61K47/24;A61K47/32;A61K47/34;A61K47/36;A61L31/00;(IPC1-7):A61K9/00

主分类号：A61K47/38

摘要：Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein each polymer of the plurality of polymers has a specified weight average molecular weight; and the polymer matrix has a broad molecular weight distribution of the plurality of polymers; a solvent having a miscibility in water of less than or equal to 7 wt% at 25°C, in an amount effective to plasticize the polymer and form a gel therewith; and a beneficial agent. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implantable beneath a patient's body surface by injection.