2aCOE-C-METHYL-3aCOE-O-L-VALINE ESTER RIBOFURANOSYL CYTIDINE FOR TREATMENT OF FLAVIVIRIDAE INFECTIONS.,申请号MX2004PA12802-传众专利搜索

2aCOE-C-METHYL-3aCOE-O-L-VALINE ESTER RIBOFURANOSYL CYTIDINE FOR TREATMENT OF FLAVIVIRIDAE INFECTIONS.

申请公布号：MXPA04012802(A)

申请号：MX2004PA12802

申请日期：2003.06.27

申请公布日期：2005.04.19

申请人：

IDENIX (CAYMAN) LIMITED

发明人：SOMMADOSSI, JEAN-PIERRE

分类号：C07H19/067;A61K9/20;A61K9/48;A61K31/7068;A61K31/7072;A61K38/21;A61K45/00;A61P1/16;A61P31/14;A61P43/00;C07H19/06;(IPC1-7):A61K00/00;A61K31/70

主分类号：C07H19/067

摘要：<p>The 3'-L-valine ester of beta-D-2'-C-methyl-ribofuranosyl cytidine provides superior results against flaviviruses and pestiviruses, including hepatitis C virus. Based on this discovery, compounds, compositions, methods and uses are provided for the treatment of flaviviridae, including HCV, that include the administration of an effective amount of val-mCyd or its salt, ester, prodrug or derivative, optionally in a pharmaceutically acceptable carrier. In an alternative embodiment, val-mCyd is used to treat any virus that replicates through an RNA-dependent RNA polymerase.</p>