Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof

申请公布号：US2004224327(A1)

申请号：US20030750409

申请日期：2003.12.30

申请公布日期：2004.11.11

申请人：

MEULENBERG JOHANNA JACOBA MARIA;POL JOHANNES MARIA ANTONIUS;BOS-DE RUIJTER JUDY NORMA ALETTA

发明人：MEULENBERG JOHANNA JACOBA MARIA;POL JOHANNES MARIA ANTONIUS;BOS-DE RUIJTER JUDY NORMA ALETTA

分类号：A61K39/00;C07K14/08;(IPC1-7):C12Q1/68

主分类号：A61K39/00

摘要：An infectious clone based on the genome of a wild-type RNA virus is produced by the process of providing a host cell not susceptible to infection by the wild-type RNA virus, providing a recombinant nucleic acid based on the genome of the wild-type RNA virus, transfecting the host cell with the recombinant nucleic acid and selecting for infectious clones. The recombinant nucleic acid comprises at least one full-length DNA copy or in vitro-transcribed RNA copy or a derivative of either. The infectious clones can be used in single or dual purpose vaccines and in viral vector vaccines.

ELECTROSTATIC COPYING APPARATUS

A REARVIEW MIRROR HAVING AN ELECTRONIC INSTRUMENT DISPLAY.

ELEKTRISK ENERGIKILDE TIL EN MODSTANDSSVEJSEMASKINE

Chair.

Hologram scanner.

Packing in a device for treating material passing through a conduit.

Process for forming a corrosion-resistant coating of a solid lubricant.

FUMIGATION DISPENSING DEVICE

Planar oscillator having a dielectric cavity and operative under microwave frequencies.

AZIDO-, AMINO- AND PROTECTED AMINOAZETIDINYLACETIC ACID DERIVATIVES

CEPHALOSPORINS

INSULATION BARRIER

IRRADIATION OF POLYMERS

4-TRIFLUOROMETHYLBENZOIC ACID DERIVATIVES

Transparent polyamides, process for their preparation and their use in the manufacture of mouldings.

Apparatus for lighting a flare stack.

Sheet for the absorption of several liquids, especially hydrocarbons.

Single-legged support structure for display panels.

Novel crystalline microporous three-dimensionally ordered solid.

Method and apparatus for use in connection with the adjustment of printing presses.